This brief synthesises the findings of forward-looking activities that were recently carried out in different European countries with a focus on research and innovation. In order to structure the activities’ outcomes, a framework is used that distinguishes different types of outcomes. The findings of the activities are then presented along this framework. The last section suggests some conclusions for European-level, challenge-driven research and innovation priority setting. The study was conducted for the expert group Global Europe 2030-2050 http://ec.europa.eu/research/social-sciences/fwl-experts-groups_en.html and financed by the European Commission’s Social Science & Humanities Programme.